Advances in carbohydrate chemistry and biochemistry. Volume 66 [electronic resource] / edited by Derek Horton
- Published:
- Waltham, MA : Elsevier Academic Press, 2011.
- Physical Description:
- 1 online resource (456 pages)
- Additional Creators:
- Horton, Derek, 1932-
Access Online
- ScienceDirect: ezaccess.libraries.psu.edu
- Contents:
- Machine generated contents note: Anthony Charles Richardson (1935-2011) / Karl J. Hale -- Detection and Structural Characterization of Oxo-Chromium(V)-Sugar Complexes by Electron Paramagnetic Resonance / Sabine Van Doorslaer -- I.Introduction -- 1.Introduction to Chromium (Bio)chemistry -- 2.State-of-the-Art EPR Techniques -- II.General Aspects of EPR of Oxo-Cr(V) Complexes -- III.Systematic Structural Characterization of Oxo-Cr(V)-Sugar Complexes Using EPR -- 1.Complexes with Alditols -- 2.Complexes with Aldohexoses and Aldopentoses -- 3.Complexes with Methyl Glycosides -- 4.Oxo-Cr(V) Complexes with Other Sugars -- 5.Complexes with Hydroxy Acids: Alduronic and Glycaric Acids -- 6.Complexes with Oligosaccharides and Polysaccharides -- IV.Conclusions -- Acknowledgments -- References -- Synthesis and Properties of Septanose Carbohydrates / Mark W. Peczuh -- I.Introduction -- II.Synthesis of Septanose-Containing Mono-, Di-, and Oligo-Saccharides -- 1.Cyclization via C---O Bond Formation -- 2.Preparation and Reactions of Carbohydrate-Based Oxepines -- 3.Miscellaneous Septanose Syntheses -- 4.Transannular Reactions of Septanose Sugars -- III.Conformational Analysis of Septanose Monosaccharides -- 1.Observed Low-Energy Conformations -- 2.Determination of Septanose Conformations -- IV.Biochemical and Biological Investigations Using Septanose Carbohydrates -- 1.Olgonucleotides Containing Septanosyl Nucleotides -- 2.Protein-Septanose Interactions -- 3.Additional Reports -- V.Outlook -- Acknowledgments -- References -- Imino Sugars and Glycosyl Hydrolases: Historical Context, Current Aspects, Emerging Trends / Tanja M. Wrodnigg -- I.Introduction -- 1.Discovery of Imino Sugars as Natural Products -- 2.Early Synthetic Efforts -- II.Glycoside Hydrolases -- 1.General Features and Means of Classification -- 2.Historical Background and Development -- III.Glycon Structure, Functional Groups, and Catalysis -- 1.β-Glucosidases and Nonnatural Substrates -- 2.β-Galactosidases and Nonnatural Substrates -- 3.α-Glucosidases and Nonnatural Substrates -- 4.α-Galactosidases and Nonnatural Substrates -- 5.α-Mannosidases and Nonnatural Substrates -- IV.Glycosidase Inhibitors -- 1.High-Molecular-Weight Inhibitors -- 2.Small Molecules: Covalent ("Irreversible"), Competitive (Reversible), and Noncompetitive (Allosteric) Inhibitors -- 3.Nonsugar Inhibitors -- 4.Carbohydrate-Related Inhibitors -- V.Imino Sugars -- 1.pKa Value and State of Ionization Approaching the Active Site -- 2.Stereochemical Considerations Concerning the Catalytic Protonation Process -- 3.Significance of Individual Functional Groups to Recognition and Binding -- 4.Deoxyfluoro Derivatives as Active-Site Probes -- 5.Imino Sugars as Active-Site Ligands for Structure and Catalysis Visualization -- 6."Non-Glycon" Binding Sites and Inhibitor Activity -- VI.Conclusions -- VII.Paradigm Changes and Emerging Topics -- VIII.Table of PDB-Entries: Enzyme-Inhibitor Complexes of Imino Sugars and Selected Other Ligands -- Acknowledgment -- References.
- Summary:
- Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that bring together industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field.
- Subject(s):
- Genre(s):
- ISBN:
- 9780123855183 (electronic bk.)
0123855187 (electronic bk.) - Note:
- AVAILABLE ONLINE TO AUTHORIZED PSU USERS.
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