Actions for Neuroinflammation in neuronal death and repair [electronic resource]

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Neuroinflammation in neuronal death and repair [electronic resource] / edited by Giacinto Bagetta, M. Tiziana Corasaniti, Stuart A. Lipton

Published
Amsterdam ; Boston : Elsevier Academic Press, [2007]
Copyright Date
©2007
Physical Description
1 online resource (xxiv, 474 pages, 26 unnumbered pages of plates) : illustrations (some color)
Additional Creators
Bagetta, Giacinto, Corasaniti, M. Tiziana, and Lipton, Stuart A.
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Contents
Cover -- Contents -- Contributors -- Preface -- Foreword -- Chapter 1: Inflammatory Mediators Leading to Protein Misfolding and Uncompetitive/Fast Off-Rate Drug Therapy for Neurodegenerative Disorders -- I. Introduction -- II. Protein Misfolding in Neurodegenerative Diseases -- III. Generation of RNS/ROS -- IV. Protein S-Nitrosylation and Neuronal Cell Death -- V. Parkin and the UPS -- VI. S-Nitrosylation and Parkin -- VII. The Unfolded Protein Response and PDI -- VIII. S-Nitrosylation of PDI Mediates Protein Misfolding and Neurotoxicity in Cell Models of PD or AD -- IX. PDI Activity in ALS and Prion Disease -- X. Potential Treatment of Excessive NMDA-Induced Ca2+ Influx and S-Nitrosylation -- XI. Looking to the Future: NitroMemantines -- XII. Conclusions -- Acknowledgments -- References -- Chapter 2: Innate Immunity and Protective Neuroinflammation: New Emphasis on the Role of Neuroimmune Regulatory Proteins -- I. Characteristics of the Cellular and Molecular Innate Immune Responses in the Brain -- II. Innate Immune Response in Health: The Key Role of Physical Barriers -- III. Immunoprivileged Status of the Brain by Preventing the Infiltration of Potentially Harmful Systemic Immune Cells: Roles of ACAMPs -- IV. Protective Innate Immune Response During Brain Infection and Inflammation to Promote the Clearance of Pathogens: Roles of PAMPs -- V. Interactions of Innate Immune Molecules with Toxic Proteins: Roles of PPAMPs -- VI. Regulating the Innate Immune Response in the CNS While Promoting Tissue Repair: Roles of Neuroimmune Regulatory Molecules -- VII. Innate Immunity and Neurogenesis -- VIII. The Canonical Innate Immune System in the CNS: The Complement System -- IX. Conclusion: Elements to Drive Innate Immune Neuroprotective Activities -- Glossary -- References -- Chapter 3: Glutamate Release from Astrocytes in Physiological Conditions and in Neurodegenerative Disorders Characterized by Neuroinflammation -- I. Introduction -- II. Ca2+-Dependent Glutamate Release from Astrocytes -- III. Excitotoxicity Involving Ca2+-Dependent Glutamate Release from Astrocytes in Pathological Conditions: The Case of ADC -- IV. Astrocytic Alterations and Ca2+-Dependent Glutamate Release Dysfunction in AD -- V. Conclusions -- References -- Chapter 4: The High-Mobility Group Box 1 Cytokine Induces Transporter-Mediated Release of Glutamate from Glial Subcellular Particles (Gliosomes) Prepared from in Situ-Matured Astrocytes -- I. Introduction -- II. Gliosomes as a Model to Study Astrocyte Characteristics -- A. Characterization of the Gliosome Preparation -- B. Glutamate Release in Gliosomes -- C. Expression of Proteins of the Release Machinery in Gliosomes -- III. HMGB1-Induced Glutamate Release from Gliosomes -- A. Cytokine Properties of HMGB1 -- B. Effect of HMGB1 on Glutamate Release from Gliosomes and Synaptosomes -- C. Mechanisms of the HMGB1-Induced Release of Glutamate from Gliosomes -- D. HMGB1 Binding to Gliosomes -- IV. Concluding Remarks -- Acknowledgments -- References -- Chapter 5: The Role of Astrocytes and Complement System in Neural Plasticity -- I. Introduction -- II. Astrocytes, GFAP, and Astrocyte Intermediate Filaments -- III&#
Summary
A current review of the mechanisms of neuroinflammation and their role in neurodegenerative disorders.
Subject(s)
Genre(s)
ISBN
9780080550565 (electronic bk.)
0080550568 (electronic bk.)
0123739896 (electronic bk.)
9780123739896 (electronic bk.)
Note
AVAILABLE ONLINE TO AUTHORIZED PSU USERS.
Bibliography Note
Includes bibliographical references and index.
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