Nutritional supplements for age-related macular degeneration [electronic resource] : a systematic review / prepared for, Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service ; prepared by, Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center ; investigators, Devan Kansagara ... [et al.].
- Washington, DC : Dept. of Veterans Affairs, Health Services Research & Development Service, 2012.
- Physical Description:
- 1 online resource (1 PDF file (43 p.)).
- Additional Creators:
- Kansagara, Devan
United States. Department of Veterans Affairs. Health Services Research and Development Service
Portland VA Medical Center. Evidence-based Synthesis Program Center
- Evidence-based synthesis program
- Restrictions on Access:
- License restrictions may limit access.
- Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the developed world. In 2004, AMD affected 1.75 million persons in the United States, a number that is expected to rise to nearly 3 million by 2020 due to the aging of the population. The severity of macular degeneration ranges from Category 1 (least severe) to Category 4 (most severe), and "advanced AMD" is defined as having geographic atrophy involving the center of the macula or features of choroidal neovascularization. Observational studies suggest that people with dietary intakes higher in various carotenoids, antioxidants and omega-3 fatty acids have a lower risk of developing AMD. This has led to several supplementation trials designed to examine the ability of nutritional supplement with carotenoids, antioxidants, or omega-3 fatty acids to prevent the progression of AMD. Our report focuses on the evidence documenting the potential benefits and harms of certain dietary supplements in patients with AMD. We conducted a systematic review of published literature to address the following key questions: In patients with age-related macular degeneration, do nutritional supplements containing carotenoids, antioxidants, or omega-3 fatty acids alone or in combination prevent functional visual loss? In adult populations, what are the harms of carotenoid, antioxidant, and omega-3 fatty acid supplementation?
- "January 2012."
- Bibliography Note:
- Includes bibliographical references.
- Funding Information:
- Prepared for: Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC 20420. Prepared by: Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR, Devan Kansagara, MD, MCR, Director
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