Actions for New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids [electronic resource]

Email RIS file
Bookmark
Report an Issue

New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids [electronic resource] / by Ana Escribano Cuesta

Author
Escribano Cuesta, Ana
Published
Cham : Springer International Publishing : Imprint: Springer, 2013.
Physical Description
XIII, 195 pages 280 illustrations, 41 illustrations in color : online resource
Additional Creators
SpringerLink (Online service)
Access Online

Availability

I Want It
I Want It

Finding items...

Series
Contents
Introduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines.
Summary
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
Subject(s)
ISBN
9783319007021
Digital File Characteristics
text file PDF
Note
AVAILABLE ONLINE TO AUTHORIZED PSU USERS.
Part Of
Springer eBooks
View MARC record | catkey: 11536449