Actions for Tumor-Induced Immune Suppression [electronic resource] : Mechanisms and Therapeutic Reversal

Email RIS file
Bookmark
Report an Issue

Tumor-Induced Immune Suppression [electronic resource] : Mechanisms and Therapeutic Reversal / edited by Dmitry I. Gabrilovich, Arthur Andrew Hurwitz

Author
Gabrilovich, Dmitry I.
Published
New York, NY : Springer New York : Imprint: Springer, 2014.
Edition
2nd ed. 2014.
Physical Description
XIV, 464 pages 38 illustrations, 34 illustrations in color : online resource
Additional Creators
Hurwitz, Arthur Andrew and SpringerLink (Online service)
Access Online

Availability

I Want It
I Want It

Finding items...

Contents
Preface.- Regulatory T Cells and Cancer -- Th17 cells in cancer -- Mast cells and immune response in cancer -- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Angiogenesis and Immune Suppression in Cancer -- Tim-3 Regulation of Cancer Immunity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment -- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer -- IDO in Inflammatory Programming and Immune Suppression in Cancer -- Defining the Fate and Function of Effector T cells through Galectin-1 – Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity -- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment -- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer -- Index.
Summary
Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer  and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy  to provide breakthroughs in cancer treatment.  It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance,  but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune  suppression to make any progress in the field and this monograph provides these important insights.
Subject(s)
ISBN
9781489980564
Digital File Characteristics
text file PDF
Part Of
Springer eBooks
View MARC record | catkey: 11943585