Chemical Mutagens [electronic resource] : Principles and Methods for Their Detection Volume 8 / edited by Frederick J. Serres

Author: Serres, Frederick J.
Published: Boston, MA : Springer US, 1983.
Physical Description: online resource
Additional Creators: SpringerLink (Online service)

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Contents

1 Detection of Effects of Mutagens in Human Populations -- 1. Introduction -- 2. Monitoring Progeny for Evidence of Germ-Cell Mutations -- 3. Detection of Gene Mutations in Somatic Cells -- 4. Nongenetic Indicators of Mutagen Exposure -- 5. Testing for Mutagenic Substances in Body Fluids -- 6. Detection of Altered Sperm -- 7. Summary -- 8. References -- 2 The Use of Intact Cellular Activation Systems in Genetic Toxicology Assays -- 1. Introduction -- 2. Mammalian Cell Mutagenesis -- 3. Bacterial Mutagenesis -- 4. Sister Chromatid Exchange and Chromosome Aberrations -- 5. Cell-Mediated Transformation -- 6. Cytotoxicity and Nucleic Acid Interactions -- 7. Discussion -- 8. Summary -- 9. References -- 3 The Mouse Spot Test As a Predictor of Heritable Genetic Damage and Other Endpoints -- 1. Introduction -- 2. Relation to Measures of Heritable Mutations -- 3. Relation to Other Endpoints -- 4. Summary -- 5. References -- 4 The Bone Marrow Micronucleus Assay: Rationale for a Revised Protocol -- 1. Introduction -- 2. Kinetics of Erythropoiesis -- 3. Rationale for the Basic Aspects of the Protocol -- 4. Protocol -- 5. Statistical Analysis -- 6. Conclusions -- 7. References -- 5 Relationships between the Chemical Structure and Mutagenic Activity of Monocyclic Aromatic Amines -- 1. Introduction -- 2. Bacterial Strains -- 3. Experimental Methods -- 4. Chemicals -- 5. Mutagenicity Data and Their Interpretation -- 6. Possible Pitfalls in Studies of Structure-Activity Relationships -- 7. Conclusions -- 8. References -- 6 The Measurement of Recessive Lethal Mutations in the Mouse -- 1. Introduction -- 2. Haldane’s Method of Detecting Lethals -- 3. The Backcross Method of Detecting Lethals -- 4. Irradiation Treatment of Male Germ Cells -- 5. Irradiation Treatment of Female Germ Cells -- 6. Chemical Mutagen Induction of Recessive Lethal Mutations -- 7. Dominant Effects of Recessive Lethal Mutations -- 8. Conclusions -- 9. References -- 7 Chemically Induced Changes in Sperm in Animals and Humans -- 1. Introduction -- 2. The F0 Mouse Sperm Head Morphology Assay -- 3. The F1 Sperm Head Morphology Assay -- 4. Induced Sperm Abnormalities in Humans -- 5. Implications of Alterations in Human Sperm Quality -- 6. The Advantages of Sperm Assays -- 7. Recommendations for Future Research and Development -- 8. References -- 8 Mutational Analysis in Cultured Human-Hamster Hybrid Cells -- 1. Introduction -- 2. Origin of Specific Lethal Antisera and Human-Hamster Hybrid Cells -- 3. Characterization of the AL Hybrid -- 4. Mutation Studies -- 5. Conclusions -- 6. References -- 9 Genetic Toxicology of Some Known or Suspected Human Carcinogens -- 1. Introduction -- 2. Chemical Selection -- 3. Method of Literature Review -- 4. Results -- 5. Discussion -- 6. Summary and Conclusions -- 7. Appendix: Complete Data Base -- 8. References -- 10 Control of Commercial Chemicals: The Sixth Amendment to the Directive on Dangerous Chemical Substances (79/83 I/EEC) Adopted by the Council of the European Communities -- 1. Introduction -- 2. Text of the Sixth Amendment to the Directive on Dangerous Chemical Substances Adopted by the Council of the European Communities -- 3. References.

Subject(s)

Chemistry

ISBN

9781461336945

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text file PDF

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