Technological challenges in antibiotic discovery and development : a workshop summary / Douglas Friedman and Joe Alper, rapporteurs ; Chemical Sciences Roundtable, Board on Chemical Sciences and Technology, Division on Earth and Life Studies, National Research Council of the National Academies
- Author
- Friedman, Douglas C.
- Published
- Washington, D.C. : National Academies Press, [2014]
- Physical Description
- xiii, 34 pages : color illustrations ; 28 cm
- Additional Creators
- Alper, Joe, National Research Council (U.S.). Chemical Sciences Roundtable, National Research Council (U.S.). Board on Chemical Sciences and Technology, and National Research Council (U.S.). Division on Earth and Life Studies
Online Version
- National Academies: www.nap.edu
- Contents
- Machine generated contents note: 1.Introduction And Overview -- Organization of the Workshop Summary -- A View from the Antibiotic Resistance Battlefield -- References -- 2.Challenges In Overcoming Antibiotic Resistance -- Selecting Antibacterial Targets to Avoid Resistance Selection -- The Complex Resistance Machineries for β-Lactam Antibiotics in Gram-Negative and Gram-Positive Bacteria -- Discussion -- References -- 3.Challenges In Screening -- Challenges in Discovering New Antibiotics Through Screening -- News Way of Looking at Old Antibiotics and Their Targets -- Discussion -- References -- 4.Challenges In Drug Delivery -- Novel Approaches to Antimicrobial Therapeutic Design -- Overcoming Antibiotic Challenges in Biofilm-Associated Infection -- Discussion -- References -- 5.General Observations -- Appendixes -- A.Statement of Task -- B.Workshop Agenda -- C.Biographical Information.
- Summary
- "Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic discovery and examine the technology available to facilitate development. Through formal presentations and panel discussions, participants from academia, industry, federal research agencies discussed the technical challenges present and the incentives and disincentives industry faces in antibiotic development, and identified novel approaches to antibiotic discovery. Antibiotic resistance is a serious and growing problem in modern medicine and it is emerging as a pre-eminent public health threat. Each year in the United States alone, at least two million acquire serious infections with bacteria that are resistant to one or more antibiotics, and at least 23,000 people die annually as a direct result of these antibiotic-resistant infections. In addition to the toll on human life, antibiotic-resistant infections add considerable and avoidable costs to the already overburdened U.S. health care system. This report explores the challenges in overcoming antibiotic resistance, screening for new antibiotics, and delivering them to the sites of infection in the body. The report also discusses a path forward to develop the next generation of potent antimicrobial compounds capable of once again tilting the battle against microbial pathogens in favor of humans. Technological Challenges in Antibiotic Discovery and Development gives a broad view of the landscape of antibiotic development and the technological challenges and barriers to be overcome."--Publisher's description
- Subject(s)
- ISBN
- 9780309298148
0309298148 - Bibliography Note
- Includes bibliographical references.
- Other Forms
- Also issued online.
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