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Coupled Flow-Biochemistry Simulations of DynamicSystems of Blood Cells

Author
Gaskin, Byron
Published
[University Park, Pennsylvania] : Pennsylvania State University, 2014.
Physical Description
1 electronic document
Additional Creators
Kunz, Robert and Craven, Brent
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Graduate Program
Restrictions on Access
Open Access.
Summary
With the aim of improved modeling of biological cell flow simulations, a computational tool has been developed to model a heterogeneous system comprised of an arbitrary number of bodies of arbitrary geometry interacting in highly viscous flows. Accordingly, this model couples computational fluid dynamics (CFD), six degree-of-freedom (6DOF) motion, and surface biochemistry. Adaptive mesh refinement is used to ensure adequate resolution of flow features when multiple surfaces are in close proximity. The particular contributions of this thesis include: 1) stability analysis of the coupled 6DOF-hydrodynamics system, leading to an efficient adaptive timestep specification, 2) introduction of the immersed boundary method (IBM), wherein arbitrary cell shapes are meshed internally, to enable exact inertial property evaluations, and 3) generalization to an n-body system including a novel cyclic method for reintroducing cells on periodic boundaries to enable statistical stationarity.These and other improvements presented in this thesis have led to a tool with improved modeling accuracy and computer run times that are orders of magnitude faster than its predecessor.The capabilities of this tool are demonstrated by presenting several three-dimensional cell system simulations. The presented cell system simulations are found to be in agreement with data found in the literature.
Other Subject(s)
Dissertation Note
M.S. Pennsylvania State University 2014.
Reproduction Note
Library holds archival microfiches negative and service copy. 1 fiche. (Micrographics International, 2015)
Technical Details
The full text of the dissertation is available as an Adobe Acrobat .pdf file ; Adobe Acrobat Reader required to view the file.
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