Reenacting the birth of an intron [electronic resource].
- Berkeley, Calif. : Lawrence Berkeley National Laboratory, 2011. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Additional Creators:
- Lawrence Berkeley National Laboratory and United States. Department of Energy. Office of Scientific and Technical Information
- An intron is an extended genomic feature whose function requires multiple constrained positions - donor and acceptor splice sites, a branch point, a polypyrimidine tract and suitable splicing enhancers - that may be distributed over hundreds or thousands of nucleotides. New introns are therefore unlikely to emerge by incremental accumulation of functional sub-elements. Here we demonstrate that a functional intron can be created de novo in a single step by a segmental genomic duplication. This experiment recapitulates in vivo the birth of an intron that arose in the ancestral jawed vertebrate lineage nearly half a billion years ago.
- Published through SciTech Connect., 07/01/2011., "lbnl-5050e", Nature Communications FT, Hellsten, Uffe; Rokhsar, Daniel S.; Aspden, Julie L.; Rio, Donald C., and Genomics Division
- Funding Information:
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