Actions for A C. elegans-based foam for rapid on-site detection of residual live virus [electronic resource].

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A C. elegans-based foam for rapid on-site detection of residual live virus [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2012.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
76 pages : digital, PDF file
Additional Creators
Sandia National Laboratories, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
In the response to and recovery from a critical homeland security event involving deliberate or accidental release of biological agents, initial decontamination efforts are necessarily followed by tests for the presence of residual live virus or bacteria. Such 'clearance sampling' should be rapid and accurate, to inform decision makers as they take appropriate action to ensure the safety of the public and of operational personnel. However, the current protocol for clearance sampling is extremely time-intensive and costly, and requires significant amounts of laboratory space and capacity. Detection of residual live virus is particularly problematic and time-consuming, as it requires evaluation of replication potential within a eukaryotic host such as chicken embryos. The intention of this project was to develop a new method for clearance sampling, by leveraging Sandia's expertise in the biological and material sciences in order to create a C. elegans-based foam that could be applied directly to the entire contaminated area for quick and accurate detection of any and all residual live virus by means of a fluorescent signal. Such a novel technology for rapid, on-site detection of live virus would greatly interest the DHS, DoD, and EPA, and hold broad commercial potential, especially with regard to the transportation industry.
Report Numbers
E 1.99:sand2012-0963
sand2012-0963
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
02/01/2012.
"sand2012-0963"
Tucker, Mark David; Negrete, Oscar A.; Branda, Catherine; Hardesty, Jasper O. E.; Kaiser, Julia N.; Kozina, Carol L.; Chirica, Gabriela S.
Funding Information
AC04-94AL85000
View MARC record | catkey: 13801597