Formation and Human Risk of Carcinogenic Heterocyclic Amines Formed from Natural Precursors in Meat [electronic resource].

Published:: Washington, D.C. : United States. Dept. of Energy, 2004.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:: PDF-file: 25 pages; size: 0.3 Mbytes
Additional Creators:: Lawrence Berkeley National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information

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Summary:

A group of heterocyclic amines that are mutagens and rodent carcinogens form when meat is cooked to medium and well-done states. The precursors of these compounds are natural meat components: creatinine, amino acids and sugars. Defined model systems of dry-heated precursors mimic the amounts and proportions of heterocyclic amines found in meat. Results from model systems and cooking experiments suggest ways to reduce their formation and, thus, to reduce human intake. Human cancer epidemiology studies related to consumption of well-done meat products are listed and compared.

Report Numbers:

E 1.99:ucrl-jrnl-208240
ucrl-jrnl-208240

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Note:

Published through SciTech Connect.
11/22/2004.
"ucrl-jrnl-208240"
Nutrition Reviews 63 5 FT
Felton, J S; Knize, M G.

Funding Information:

W-7405-ENG-48

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