Modeling of the Deformation of Living Cells Induced by Atomic Force Microscopy [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 2001. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- 7p : digital, PDF file
- Additional Creators:
- Lawrence Berkeley National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- We describe finite element modeling of the deformation of living cells by atomic force microscopy (AFM). Cells are soft systems, susceptible to large deformations in the course of an AFM measurement. Often the local properties, the subject of the measurement, are obscured by the response of the cell as a whole. The Lagrangian finite deformation model we have developed and implemented in finite elements analysis offers a solution to this problem. The effect of the gross deformation of the cell can be subtracted from the experimentally measured data in order to give a reproducible value for local properties. This facilitates concurrent experimental efforts to measure the mechanical properties at specific receptor sites on the membrane of a living cell.
- Published through SciTech Connect., 12/21/2001., "ucrl-jc-146706", 2002 International Conference on Computational Nanoscience and Nanotechnology, San Juan, Puerto Rico, Apr 22 - Apr 25, 2002., and Allen, M J; Balhorn, R; Rudd, R E; McElfresh, M; Baesu, E; Belak, J.
- Funding Information:
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