Actions for Application of Sequence-based Methods in Human MicrobialEcology [electronic resource].

Email RIS file
Bookmark
Report an Issue

Application of Sequence-based Methods in Human MicrobialEcology [electronic resource].

Published
Berkeley, Calif. : Lawrence Berkeley National Laboratory, 2005.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Additional Creators
Lawrence Berkeley National Laboratory, National Institutes of Health (U.S.), and United States. Department of Energy. Office of Scientific and Technical Information
Access Online

Availability

I Want It
I Want It

Finding items...

Restrictions on Access
Free-to-read Unrestricted online access
Summary
Ecologists studying microbial life in the environment have recognized the enormous complexity of microbial diversity for many years, and the development of a variety of culture-independent methods, many of them coupled with high-throughput DNA sequencing, has allowed this diversity to be explored in ever greater detail. Despite the widespread application of these new techniques to the characterization of uncultivated microbes and microbial communities in the environment, their application to human health and disease has lagged behind. Because DNA based-techniques for defining uncultured microbes allow not only cataloging of microbial diversity, but also insight into microbial functions, investigators are beginning to apply these tools to the microbial communities that abound on and within us, in what has aptly been called the second Human Genome Project. In this review we discuss the sequence-based methods for microbial analysis that are currently available and their application to identify novel human pathogens, improve diagnosis of known infectious diseases, and to advance understanding of our relationship with microbial communities that normally reside in and on the human body.
Report Numbers
E 1.99:lbnl--58770
lbnl--58770
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
08/29/2005.
"lbnl--58770"
": KP1103010"
Genome Research 16 FT
Rubin, Edward M.; Bristow, James; Weng, Li.
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Funding Information
DE-AC02-05CH11231
626021
View MARC record | catkey: 13802185