Determining the role of the telomere on the severity of birth defects [electronic resource].
Published
Washington, D.C. : United States. Dept. of Energy, 1998. Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The work resulted in publication of eight manuscripts in peer-reviewed journals. Ten papers were presented at meetings of professional societies and one of these resulted in an award to a student for ''Outstanding Undergraduate Research.'' The research conducted under this program has had a profound effect on the characterization of a human malady, the Wolf Hirschhorn syndrome (WHS), caused by a terminal deletion of chromosome 4. The available genomic sequence and their attempts to characterize the potential transcriptional units has sharpened their focus on the development of methods to explore the functional significance of the human genome.