Inhaled /sup 239/PuO/sub 2/ and/or total-body gamma radiation [electronic resource] : Early mortality and morbidity in rats and dogs
- Published
- Rockville, Md. : U.S. Nuclear Regulatory Commission, 1988.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy. - Physical Description
- Pages: 301 : digital, PDF file
- Additional Creators
- U.S. Nuclear Regulatory Commission and United States. Department of Energy. Office of Scientific and Technical Information
Access Online
- Restrictions on Access
- Free-to-read Unrestricted online access
- Summary
- Rats and beagle dogs were given doses of /sup 60/Co gamma radiation and/or body burdens of /sup 239/PuO/sub 2/ within lethal ranges in an experiment to determine and compare morbidity and mortality responses of both species within 1 year after exposure. Radiation-induced morbidity was assessed by measuring changes in body weights, hematologic parameters, and pulmonary-function parameters. Gamma radiation caused transient morbidity, reflected by immediately depressed blood cell concentrations and by long-term loss of body weight and diminished pulmonary function in animals of both species that survived the acute gamma radiation syndrome. Inhaled plutonium caused a loss of body weight and diminished pulmonary function in both species, but its only effect on blood cell concentrations was lymphocytopenia in dogs. Combined gamma irradiation and plutonium lung burdens were synergistic, in that animals receiving both radiation insults had higher morbidity and mortality rates than would be predicted based on the effect of either kind of radiation alone. Plutonium lung burdens enhanced the effect of gamma radiation in rats within the first 30 days of exposure, and gamma radiation enhanced the long-term effect of plutonium lung burdens in both species. Rats were less sensitive to both kinds of radiation, whether administered alone or in combination. 71 refs., 105 figs., 48 tabs.
- Report Numbers
- E 1.99:nureg/cr-5198
E 1.99: pnl-6586
pnl-6586
nureg/cr-5198 - Subject(s)
- Other Subject(s)
- Beagles
- Life Span
- Lungs
- Biological Radiation Effects
- Radioactive Aerosols
- Inhalation
- Rats
- Biological Models
- Cobalt 60.
- Gamma Radiation
- Mortality
- Aerosols
- Animals
- Beta Decay Radioisotopes
- Beta-Minus Decay Radioisotopes
- Biological Effects
- Body
- Cobalt Isotopes
- Colloids
- Dispersions
- Dogs
- Electromagnetic Radiation
- Intake
- Intermediate Mass Nuclei
- Internal Conversion Radioisotopes
- Ionizing Radiations
- Isomeric Transition Isotopes
- Isotopes
- Mammals
- Minutes Living Radioisotopes
- Nuclei
- Odd-Odd Nuclei
- Organs
- Radiation Effects
- Radiations
- Radioisotopes
- Respiratory System
- Rodents
- Sols
- Vertebrates
- Years Living Radioisotopes
- Note
- Published through SciTech Connect.
08/01/1988.
"nureg/cr-5198"
" pnl-6586"
"TI88016197"
Filipy, R.E.; Scott, B.R.; Park, J.F.; Ragan, H.A.; Buschbom, R.L.; Decker, J.R.; Cannon, W.C.; Kuffel, E.G.; Lai, Y.L.; McGee, D.R.; Yaniv, S.S.; Lauhala, K.E.; Hiastala, M.P. - Funding Information
- AC06-76RL01830
View MARC record | catkey: 13803406