Evidence for Cardiomyocyte Renewal in Humans [electronic resource].

Published:: Washington, D.C. : United States. Dept. of Energy, 2008.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:: PDF-file: 55 pages; size: 3.4 Mbytes
Additional Creators:: Lawrence Berkeley National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information

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Summary:

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of ¹⁴C, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 20 to 0.3% at the age of 75. Less than 50% of cardiomyocytes are exchanged during a normal lifespan. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work towards the development of therapeutic strategies aiming to stimulate this process in cardiac pathologies.

Report Numbers:

E 1.99:llnl-jrnl-407811
llnl-jrnl-407811

Subject(s):

Basic Biological Sciences

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Note:

Published through SciTech Connect.
10/14/2008.
"llnl-jrnl-407811"
Science, vol. 324, N/A, April 3, 2009, pp. 98-102 324 ISSN 0193-4511; SCEHDK FT
Bernard, S; Walsh, S; Buchholz, B A; Bhardwaj, R D; Druid, H; Frisen, J; Bergmann, O; Zdunek, S; Barnabe-Heider, F; Zupicich, J; Alkass, K; Jovinge, S.

Funding Information:

W-7405-ENG-48

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