Life at the Single Molecule Level [electronic resource].

Published:: Washington, D.C. : United States. Dept. of Energy. Office of Science, 2011.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Additional Creators:: Brookhaven National Laboratory, United States. Department of Energy. Office of Science, and United States. Department of Energy. Office of Scientific and Technical Information

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Summary:

In a living cell, gene expression—the transcription of DNA to messenger RNA followed by translation to protein—occurs stochastically, as a consequence of the low copy number of DNA and mRNA molecules involved. Can one monitor these processes in a living cell in real time? How do cells with identical genes exhibit different phenotypes? Recent advances in single-molecule imaging in living bacterial cells allow these questions to be answered at the molecular level in a quantitative manner. It was found that rare events of single molecules can have important biological consequences.

Report Numbers:

E 1.99:bnl-83263-2011-cp
bnl-83263-2011-cp

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Published through SciTech Connect.
03/04/2011.
"bnl-83263-2011-cp"
Brookhaven Science Associates' Distinguished Lecture Series, Brookhaven National Laboratory, Upton, New York (United States), presented on March 04, 2011.
Xie, Xiaoliang Sunny.
Brookhaven Science Associates (BSA)

Funding Information:

AC02-98CH10886

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