Novel SERS materials for multiplex biomolecular detection via controlled nanoparticle linking and polymer encapsulation [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 2008.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- PDF-file: 25 pages; size: 0.8 Mbytes
- Additional Creators:
- Lawrence Berkeley National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- Over the past decade the emphasis on single-molecule sensitivity of surface-enhanced Raman spectroscopy (SERS) has brought to prominence the special role played by so-called SERS 'hot spots', oftentimes nanometer-scale junctions between nanostructures. In this report, optimally SERS enhancing silver clusters were synthesized using bifunctional linkers and polymer and/or protein encapsulation. The synthesis, which results in stable clusters even when stored for months or dried and re-dissolved, is scalable to large quantities. Using a sacrificial linker approach we also employ a permeable polymer/protein shell for general small molecule sensing. Finally, we utilize these nanomaterials by tagging specific epitopes on cancer cells and show that SERS signals from single clusters can be measured routinely.
- Report Numbers:
- E 1.99:llnl-jrnl-405971
- Other Subject(s):
- Published through SciTech Connect.
Journal of Physical Chemistry C, vol. 113, N/A, July 7, 2009, pp. 13622-13629 113 ISSN 1932-7447 FT
Lee, S J; Braun, G B; Fabris, L; Laurence, T; Moskovits, M; Bazan, G C; Reich, N O; Fera, N.
- Funding Information:
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