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A humanized anti-M2 scFv shows protective in vitro activity against influenza [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2008.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Additional Creators
Los Alamos National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar activity to the parental mAb: it is able to recognize M2 in its native context on cell surfaces and is able to show protective in vitro activity against influenza, and so represents a potential lead antibody candidate for universal prophylactic or therapeutic intervention in influenza.
Report Numbers
E 1.99:la-ur-08-07627
E 1.99: la-ur-08-7627
la-ur-08-7627
la-ur-08-07627
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Note
Published through SciTech Connect.
01/01/2008.
"la-ur-08-07627"
" la-ur-08-7627"
Protein Engineering Design and Selection FT
Bradbury, Andrew M; Schmidt, Jurgen G; Velappan, Nileena.
Funding Information
AC52-06NA25396
View MARC record | catkey: 13809458