Pseudomonas aeruginosa forms Biofilms in Acute InfectionIndependent of Cell-to-Cell Signaling [electronic resource].

Published:: Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2006.
Additional Creators:: United States. Department of Energy. Office of Scientific and Technical Information

Access Online

www.osti.gov

Availability

Finding items...

Restrictions on Access:

Free-to-read Unrestricted online access

Summary:

Biofilms are bacterial communities residing within a polysaccharide matrix that are associated with persistence and antibiotic resistance in chronic infections. We show that the opportunistic pathogen Pseudomonas aeruginosa forms biofilms within 8 hours of infection in thermally-injured mice, demonstrating that biofilms contribute to bacterial colonization in acute infections. P. aeruginosa biofilms were visualized within burned tissue surrounding blood vessels and adipose cells. Although quorum sensing (QS), a bacterial signaling mechanism, coordinates differentiation of biofilms in vitro, wild type and QS-deficient P. aeruginosa formed similar biofilms in vivo. Our findings demonstrate that P. aeruginosa forms biofilms on specific host tissues independent of QS.

Report Numbers:

E 1.99:lbnl--61664
lbnl--61664

Other Subject(s):

Note:

Published through SciTech Connect.
09/20/2006.
"lbnl--61664"
": YN0100000"
Infection and Immunity 75 8 ISSN 0019-9567; INFIBR FT
Suh, Sang J.; Auer, Manfred; Schaber, J. Andy; Triffo, W.J.; Oliver, Jeffrey W.; Hastert, Mary C.; Griswold, John A.; Hamood, Abdul N.; Rumbaugh, Kendra P.
COLLABORATION - Texas TechU.

Funding Information:

DE-AC02-05CH11231
366995

View MARC record | catkey: 13809721