Genomic sequence of the xylose fermenting, insect-inhabitingyeast, Pichia stipitis [electronic resource].

Published: Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2007.
Additional Creators: United States. Department of Energy. Office of Scientific and Technical Information

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Summary

Xylose is a major constituent of angiosperm lignocellulose,so its fermentation is important for bioconversion to fuels andchemicals. Pichia stipitis is the best-studied native xylose fermentingyeast. Genes from P. stipitis have been used to engineer xylosemetabolism in Saccharomycescerevisiae, and the regulation of the P.stipitis genome offers insights into the mechanisms of xylose metabolismin yeasts. We have sequenced, assembled and finished the genome ofP.stipitis. As such, it is one of only a handful of completely finishedeukaryotic organisms undergoing analysis and manual curation. Thesequence has revealed aspects of genome organization, numerous genes forbiocoversion, preliminary insights into regulation of central metabolicpathways, numerous examples of co-localized genes with related functions,and evidence of how P. stipitis manages to achieve redox balance whilegrowing on xylose under microaerobic conditions.

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E 1.99:lbnl--62457
lbnl--62457

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Published through SciTech Connect.
06/25/2007.
"lbnl--62457"
": KP1103010"
Nature Biotech 25 FT
Richardson, Paul M.; Aerts, Andrea; Dehal, Paramvir; Grimwood, Jane; Schmutz, Jeremy; Salamov, Asaf; Grigoriev, Igor; Shapiro, Harris; Lindquist, Erika; Jeffries, Thomas W.; Laplaza,Jose M.; Jin, Yong-Su; Passoth, Volkmar.
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)

Funding Information

DE-AC02-05CH11231
626739

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