Actions for Monitoring Gene Expression In Vivo with Nucleic Acid Molecular Switches [electronic resource].

Email RIS file
Bookmark
Report an Issue

Monitoring Gene Expression In Vivo with Nucleic Acid Molecular Switches [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2005.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Additional Creators
Yale University. School of Medicine, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
Access Online

Availability

I Want It
I Want It

Finding items...

Restrictions on Access
Free-to-read Unrestricted online access
Summary
The overall objectives of this project were (1) to develop allosteric ribozymes capable of acting as molecular switches for monitoring the levels of both wild-type and mutant mRNA species in living cells and whole animals and (2) to develop highly efficient reagents to deliver nucleic acid molecular switches into living cells, tissues and animals with the ultimate goal of expression profiling specific mRNAs of diagnostic or prognostic value within tumors in animals. During the past year, we have moved our laboratory to Nevada and in the moving process we have lost electronic and paper copies of prior progress reports concerning the construction and biological properties of the molecular switches. Since there was minimal progress during the last year on molecular switches, we are relying on past project reports to provide a summary of our data on this facet of the grant. Here we are summarizing the work done on the delivery reagents and their application to inducing mutations in living cells, which will include work done during the no cost extension.
Report Numbers
E 1.99:836260
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
01/26/2005.
David C. Ward; Patricia Bray-Ward.
Type of Report and Period Covered Note
Final;
Funding Information
FG02-00ER63058
View MARC record | catkey: 13810460