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Compact Gamma-Ray Imager for In-Vivo Gene Imaging [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy. Office of Energy Research, 2000.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
vp : digital, PDF file
Additional Creators
United States. Department of Energy. Office of Management, United States. Department of Energy. Office of Energy Research, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
A compact, low-cost, gamma-ray imaging system is needed to study gene expression in small animals. State-of-the-art electronic imaging systems have insufficient resolution and animals must be sacrificed for detailed imaging that precludes time evolution studies. With improved electronics radioactive tracers attached to gene markers can be used to track the absorption and mobility of gene therapy medications in live animals. Other instrumentation being developed for medical applications does not have the response to match the radiation source for this work. The objective of this research was to develop thick film (Cd,Zn)Te detectors matched to the gamma ray energy of ¹²⁹I. The detector would be a direct readout device using p-i-n diodes formed from the high Z material absorbing the radiation, with separate readout. Higher quality semiconducting material was expected from epitaxial growth on GaAs, a near lattice matched substrate. In practice, it was difficult to obtain material with high resistance and low leakage current. Spire Corporation achieved the goal of fabricating working detectors in (Cd,Zn)Te deposited on GaAs. The spectra of an alpha emitter (²²⁵Am) was adequately resolved in thin film devices. Thick p-i-n diodes were fabricated but other processing problems prevented full demonstration of a gamma ray detector.
Report Numbers
E 1.99:fr-60425
fr-60425
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
06/01/2000.
"fr-60425"
Greenwald, A. C.
Type of Report and Period Covered Note
Final; 09/04/1999 - 03/04/2000
Funding Information
FG02-99ER82892
View MARC record | catkey: 13811492