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Chromosomal localization and structure of the human type II IMP dehydrogenase gene [electronic resource].

Published
Washington, D.C. : United States. Dept. of Health and Human Services, 1994.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
12 pages : digital, PDF file
Additional Creators
Argonne National Laboratory, United States. Department of Health and Human Services, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
We determined the chromosomal localization and structure of the gene encoding human type II inosine 5′-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205), an enzyme associated with cellular proliferation, malignant transformation, and differentiation. Using polymerase chain reaction (PCR) primers specific for type II IMPDH, we screened a panel of human-Chinese hamster cell somatic hybrids and a separate deletion panel of chromosome 3 hybrids and localized the gene to 3p21.1→p24.2. Two overlapping yeast artificial chromosome clones containing the full gene for type II IMPDH were isolated and a physical map of 117 kb of human genomic DNA in this region of chromosome 3 was constructed. The gene for type II IMPDH was localized and oriented on this map and found to span no more than 12.5 kb.
Report Numbers
E 1.99:anl/bim/pp--77638
anl/bim/pp--77638
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
05/01/1994.
"anl/bim/pp--77638"
"DE94011499"
": Grant HG00358"
Huberman, E.; Collart, F.; Drabkin, H.; Glesne, D.; Varkony, T.
Type of Report and Period Covered Note
Topical; 12/31/1994 - 12/31/1994
Funding Information
W-31109-ENG-38
View MARC record | catkey: 13811963