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Human Genetic Marker for Resistance to Radiations and Chemicals [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy. Office of Environmental Management, 2000.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
vp : digital, PDF file
Additional Creators
Columbia University, United States. Department of Energy. Office of Environmental Management, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
The major objective of this project is to understand the genetic basis for resistance of humans to radiations and chemicals. In the fission yeast S. pombe, a gene called rad9 plays a key role in promoting resistance to DNA damaging agents and controlling cell cycle progression after radiation or chemical exposure. This investigation focuses on the characterization of a human homologue of this yeast gene, called HRAD9, with the longterm goal of developing the gene as a genetic marker to predict inherent susceptibility to the deleterious health effects caused by DNA damage. The aims concern a molecular characterization of HRAD9 and determination of its role in mediating the cellular response to radiations and chemicals, as well as its potential role in carcinogenesis.
Report Numbers
E 1.99:emsp-55100--2000
emsp-55100--2000
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
06/01/2000.
"emsp-55100--2000"
Lieberman, Howard B.
Type of Report and Period Covered Note
Annual; 06/01/2000 - 06/01/2000
Funding Information
FG07-96ER62309
EMSP 55100
View MARC record | catkey: 13811987