Genetic variation in resistance to ionizing radiation [electronic resource].

Published:: Washington, D.C. : United States. Dept. of Energy, 1989.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:: Pages: (26 pages) : digital, PDF file
Additional Creators:: University of California, Irvine. Ecology and Evolutionary Biology, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information

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Summary:

The very reactive superoxide anion O[sub 2] is generated during cell respiration as well as during exposure to ionizing radiation. Organisms have evolved different mechanisms to protect against the deleterious effects of reduced oxygen species. The copper-zinc superoxide dismutase is a eukaryotic cytoplasmic enzyme that protects the cell by scavenging superoxide radicals and dismutating them to hydrogen peroxide and molecular oxygen: 20[sub 2][sup [minus]] + 2H [yields] H[sub 2]O[sub 2] + O[sub 2]. SOD had been shown to protect against ionizing radiation damage to DNA, viruses, bacteria, mammalian cells, whole mice, and Drosophila. Evidence that genetic differences may affect sensitivity to ionizing radiation has been shown in Drosophila since differences have been shown to exist between strains and resistance to radiation can evolve under natural selection.

Report Numbers:

E 1.99:doe/er/60713-t3
doe/er/60713-t3

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Note:

Published through SciTech Connect.
01/01/1989.
"doe/er/60713-t3"
"DE93017835"
Ayala, F.J.

Funding Information:

FG03-88ER60713

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