Theoretical models for cell-cell interaction in immune responses [electronic resource].
- Los Alamos, N.M. : Los Alamos Scientific Laboratory, 1978. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- Pages: 28 : digital, PDF file
- Additional Creators:
- Los Alamos Scientific Laboratory and United States. Department of Energy. Office of Scientific and Technical Information
- Quantitative theoretical models are described for treating interactions between cells which are mediated by mutually complementary receptors or by ligands, such as antigens or antigen-antibody complexes, which can bind and form links between the cells. It is found that relatively few receptor-receptor or receptor-ligand bonds can establish firm adhesion between the cells. Conditions on receptor numbers, mobility, and binding constants are defined for rapid binding between cells. As mobile receptors diffuse into and become concentrated in regions of intercellular contact, the cell membranes will be thereby locally modified, possibly forming a contact cap. An analysis is made of the extent and rate of such receptor accumulation. Some applications of these considerations to problems in immunology are sketched.
- Published through SciTech Connect., 01/01/1978., "la-ur-78-2572", " conf-781070-1", Meeting on physical chemical aspects of cell surface events in cellular regulation, Bethesda, MD, USA, 18 Oct 1978., and Bell, G.I.
- Funding Information:
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