Kinetic model building using advanced nuclear medicine techniques [electronic resource] : the kinetics of chromium(III) in the human body. [/sup 51/Cr].

Published:: Berkeley, Calif. : University of California, Berkeley, 1978.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:: Pages: 23 : digital, PDF file
Additional Creators:: University of California, Berkeley and United States. Department of Energy. Office of Scientific and Technical Information

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Summary:

The purpose of this study is to investigate whether a valid index of chromium (III) nutritional status can be determined with satisfaction through in vivo kinetic analysis. Three normal subjects and three patients suffering from hemochromatosis were periodically scanned with the Donner Laboratory computerized whole body scanners, starting seconds after radiochromium(III) was administered intravenously, up to a period of 84 days. The activity in the liver, adipose and muscle tissues, spleen and bone was quantitated and corrected, by subtraction of the blood circulation activity in that organ; the major concentration was found in the liver and spleen. From the series of scan images, a kinetic model for the radiochromium(III) metabolic pathway was constructed. Computer analysis showed a significant difference between the two classes of subjects in organs as well as whole body radiochromium(III) transfer. Interpretation of these results showed that in patients with excessive iron stores, a smaller amount of chromium bound to plasma protein was found and a corresponding decrease in transfer of chromium into stores in the liver and other tissues was also found.

Report Numbers:

E 1.99:lbl-7473
E 1.99: conf-780948-1
conf-780948-1
lbl-7473

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Note:

Published through SciTech Connect.
06/01/1978.
"lbl-7473"
" conf-780948-1"
2. congress on nuclear medicine and biology, Washington, DC, USA, 17 Sep 1978.
Lim, T.H.

Funding Information:

W-7405-ENG-48

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