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UV-induced changes in cell cycle and gene expression within rabbit lens epithelial cells [electronic resource].

Published:
Washington, D.C. : United States. Dept. of Energy. Office of Energy Research, 1994.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:
35 pages : digital, PDF file
Additional Creators:
Argonne National Laboratory, United States. Department of Energy. Office of Energy Research, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary:
Damage to lens epithelial cells is a probable initiation process in cataract formation induced by ultraviolet radiation. These experiments investigated the ability of 254 nm radiation on cell cycle progression and gene expression in rabbit lens epithelial cell line N/N1003A. No changes in expression of c-fos, c-jun, alpha- tubulin, or vimentin was observed following UV exposure. Using flow cytometry, an accumulation of cells in G1/S phase of the cell cycle 1 hr following exposure. The observed changes in gene expression, especially the decreased histone transcripts reported here may play a role in UV induced inhibition of cell cycle progression.
Report Numbers:
E 1.99:anl/cmb/pp--84692
anl/cmb/pp--84692
Subject(s):
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Note:
Published through SciTech Connect.
11/01/1994.
"anl/cmb/pp--84692"
"DE97002719"
Grdina, D.; Woloschak, G.E.; Sidjanin, D.
Funding Information:
W-31-109-ENG-38
View MARC record | catkey: 14077423