Criteria for the selection of nuclides for radioimmunotherapy [electronic resource].
- Published:
- Cambridge, Mass. : Harvard University, 1986.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy. - Physical Description:
- Pages: 9 : digital, PDF file
- Additional Creators:
- Harvard University and United States. Department of Energy. Office of Scientific and Technical Information
Access Online
- Restrictions on Access:
- Free-to-read Unrestricted online access
- Summary:
- This report describes many factors that need to be considered if radioimmunotherapy is to become a commonplace reality. For beta-emitting radionuclides, two physical features of importance are half-life and energy, with the latter determining the range. These features must be matched to the pharmacokinetics of the carrier and the distribution of the radionuclide, both macroscopically and microscopically. Alpha-particle emitters could be considered for cells that are readily accessible to the labeled antibody and for populations that uniformly and constantly display the targeted antigen or idiotype, e.g., trafficking cells such as T or B lymphocytes. For cells that concentrate the radioactive label, the use of low-energy electrons should be examined. If the radionuclide is translocated to the nucleus, the Auger effect can be particularly lethal because of the high LET-like biological response. 15 refs., 3 figs., 2 tabs.
- Report Numbers:
- E 1.99:conf-8607355-1
conf-8607355-1 - Subject(s):
- Other Subject(s):
- Alpha Particles
- Technology Assessment
- Astatine 211
- Dosimetry
- Beta Particles
- Bismuth 212
- Electron Capture
- Fermium 255
- Radioimmunotherapy
- Auger Effect
- Biological Effects
- Biological Localization
- Cell Cultures
- Cell Killing
- Dose-Response Relationships
- Let
- Monoclonal Antibodies
- Phosphorus 32.
- Rbe
- Sensitivity
- Actinide Isotopes
- Actinide Nuclei
- Alpha Decay Radioisotopes
- Antibodies
- Astatine Isotopes
- Beta Decay Radioisotopes
- Beta-Minus Decay Radioisotopes
- Bismuth Isotopes
- Capture
- Charged Particles
- Days Living Radioisotopes
- Electron Capture Radioisotopes
- Energy Transfer
- Even-Odd Nuclei
- Fermium Isotopes
- Heavy Nuclei
- Hours Living Radioisotopes
- Immunology
- Isotopes
- Light Nuclei
- Medicine
- Nuclear Medicine
- Nuclei
- Odd-Even Nuclei
- Odd-Odd Nuclei
- Phosphorus Isotopes
- Radioimmunology
- Radioisotopes
- Radiology
- Radiotherapy
- Therapy
- Note:
- Published through SciTech Connect.
01/01/1986.
"conf-8607355-1"
"DE88002584"
Symposium on radiolabeled monoclonal antibodies for imaging and therapy: potential, problems, and prospects, Pascoli, Italy, 20 Jul 1986.
Adelstein, S.J.; Kassis, A.I. - Funding Information:
- FG02-86ER60460
View MARC record | catkey: 14081838