Actions for Identification of cell density signal molecule [electronic resource].

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Identification of cell density signal molecule [electronic resource].

Published
Berkeley, Calif. : Lawrence Berkeley National Laboratory, 1998.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Additional Creators
Lawrence Berkeley National Laboratory and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.
Report Numbers
E 1.99:us 5741895
us 5741895
Other Subject(s)
Note
Published through SciTech Connect.
01/01/1998.
"us 5741895"
Schwarz, Richard I.
Funding Information
AC03-76SF00098
View MARC record | catkey: 14101096