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Microchip device for liquid phase analysis [electronic resource].

Published
Washington, D.C : United States. Dept. of Energy. Office of the Assistant Secretary for Defense Programs, 2000.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
22 pages : digital, PDF file
Additional Creators
United States. Department of Energy. Office of the Assistant Secretary for Defense Programs and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
The lab-on-a-chip concept has enabled miniature instruments to be developed that allow the rapid execution and automation of fluidic operations such as valving, separation, dilution, mixing, and flow splitting upon the proper application of a motive (driving) force. The integration of these simple operations to perform complete, multiple-step chemical assays is rapidly becoming a reality. Such compact, monolithic devices potentially enjoy advantages in speed, cost, automation, reagent consumption, and waste generation compared to existing laboratory-scale instruments. Initial reports of these microfluidic devices focused on combining various electrokinetically driven separation methods including microchip electrophoresis, gel electrophoresis, micellar electrokinetic chromatography (MEKC) and open channel electrochromatography (OCEC) with fluidic valving to introduce sample plugs into the separation channel. Other operations have quickly been integrated with the separations and fluidic valving on these microchips. For example, integrated devices with mixers/diluters for precolumn and postcolumn analyte derivatization, deoxyribonucleic acid (DNA) restriction digests, enzyme assays, and polymerase chain reaction (PCR) amplification have been added to the basic design. Integrated mixers that can perform solvent programming for both MEKC and OCEC have also been demonstrated. These examples are simple, yet powerful, demonstrations of the potential for lab-on-a-chip devices. In this report, three key areas for improved performance of these devices are described: on-chip calibration techniques, enhanced separative performance, and enhanced detection capabilities.
Report Numbers
E 1.99:y/nsp-305
y/nsp-305
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
05/01/2000.
"y/nsp-305"
Ramsey, j.m.
Oak Ridge Y-12 Plant, TN (US)
Type of Report and Period Covered Note
Final; 05/01/2000 - 05/01/2000
Funding Information
AC05-84OR21400
View MARC record | catkey: 14107506