Actions for Final report on LDRD project [electronic resource] : Semiconductor surface-emitting microcavity laser spectroscopy for analysis of biological cells and microstructures

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Final report on LDRD project [electronic resource] : Semiconductor surface-emitting microcavity laser spectroscopy for analysis of biological cells and microstructures

Published
Washington, D.C. : United States. Dept. of Energy. Office of Energy Research, 1997.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
30 pages : digital, PDF file
Additional Creators
Sandia National Laboratories, United States. Department of Energy. Office of Energy Research, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
This article discusses a new intracavity laser technique that uses living or fixed cells as an integral part of the laser. The cells are placed on a GaAs based semiconductor wafer comprising one half of a vertical cavity surface-emitting laser. After placement, the cells are covered with a dielectric mirror to close the laser cavity. When photo-pumped with an external laser, this hybrid laser emits coherent light images and spectra that depend sensitively on the cell size, shape, and dielectric properties. The light spectra can be used to identify different cell types and distinguish normal and abnormal cells. The laser can be used to study single cells in real time as a cell-biology lab-on-a-chip, or to study large populations of cells by scanning the pump laser at high speed. The laser is well-suited to be integrated with other micro-optical or micro-fluidic components to lead to micro-optical-mechanical systems for analysis of fluids, particulates, and biological cells.
Report Numbers
E 1.99:sand--97-1988
sand--97-1988
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
08/01/1997.
"sand--97-1988"
"DE97009148"
McDonald, A.E.; Gourley, P.L.; Gourley, M.F.; Bellum, J.
Funding Information
AC04-94AL85000
View MARC record | catkey: 14110598