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Mode pumping experiments on biomolecules [electronic resource].

Published
Upton, N.Y. : Brookhaven National Laboratory, 1995.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
pages Th4.23 : digital, PDF file
Additional Creators
Brookhaven National Laboratory and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
We will explore several aspects of protein dynamics and energy transfer that can be explored by using the intense, picosecond, tunable mid-IR output of the FEL. In order of appearance they are: (1) Saturation recovery and inter-level coupling of the low temperature amide-I band in acetanilide. This is a continuation of earlier experiments to test soliton models in crystalline hydrogen bonded solids. In this experiment we utilize the sub-picosecond time resolution and low repetition rate of the Stanford SCLA FEL to do both T₁ and T₂ relaxation measurements at 1650 cm⁻¹. (2) Probing the influence of collective dynamics in sensory rhodopsin. In this experiment we use the FIR output of the Stanford FIREFLY FEL to determine the lifetime of collective modes in the photo-active protein sensory rhodopsin, and begin experiments on the influence of collective modes on retinal reaction dynamics. (3) Probing the transition states of enzymes. This experiment, in the initial stages, attempts to use the intense IR output of the FEL to probe and influence the reaction path of a transition state analog for the protein nucleoside hydrolase. The transition state of the inosine substrate is believed to have critical modes softened by the protein so that bond-breaking paths show absorption at approximately 800 cm⁻¹. A form of action spectrum using FEL excitation will be used to probe this state.
Report Numbers
E 1.99:bnl--61982-absts.
E 1.99: conf-9508156--absts.
conf-9508156--absts.
bnl--61982-absts.
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Note
Published through SciTech Connect.
12/31/1995.
"bnl--61982-absts."
" conf-9508156--absts."
"DE96002729"
17. international free electron laser conference, New York, NY (United States), 21-25 Aug 1995.
Austin, R.H.; Schramm, A.; Erramilli, S.; Xie, A.
View MARC record | catkey: 14111576