Bioavailability Of Organic Solvents In Soils [electronic resource] : Input Into Biologically Based Dose-Response Models for Human Risk Assessments
- Washington, D.C. : United States. Dept. of Energy. Office of Environmental Management, 2000.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- vp : digital, PDF file
- Additional Creators:
- University of California, San Francisco, United States. Department of Energy. Office of Environmental Management, and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- The purpose of this study is to determine the bioavailability of organic solvents following dermal exposures to contaminated soil and water. Breath analysis is being used to obtain real-time measurements of volatile organics in expired air following exposure in rats and humans. Rhesus monkeys were used as surrogates for humans in benzene exposures. The exhaled breath data was analyzed using physiologically based pharmacokinetic (PBPK) models to determine the dermal bioavailability of organic solvents under realistic exposure conditions. The end product of this research will be a tested framework for the rapid screening of real and potential exposures while simultaneously developing PBPK models to comprehensively evaluate and compare exposures to organic compounds from either contaminated soil or water.
- Report Numbers:
- E 1.99:emsp-59828
- Other Subject(s):
- Published through SciTech Connect.
Wester, Ronald C.
- Type of Report and Period Covered Note:
- Final; 12/31/2000 - 12/31/2000
- Funding Information:
View MARC record | catkey: 14137661