Problems in mechanistic theoretical models for cell transformation by ionizing radiation [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 1991. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- 8 pages : digital, PDF file
- Additional Creators:
- Lawrence Berkeley National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- A mechanistic model based on yields of double strand breaks has been developed to determine the dose response curves for cell transformation frequencies. At its present stage the model is applicable to immortal cell lines and to various qualities (X-rays, Neon and Iron) of ionizing radiation. Presently, we have considered four types of processes which can lead to activation phenomena: (1) point mutation events on a regulatory segment of selected oncogenes, (2) inactivation of suppressor genes, through point mutation, (3) deletion of a suppressor gene by a single track, and (4) deletion of a suppressor gene by two tracks.
- Published through SciTech Connect., 10/01/1991., "lbl--31398", " conf-9109107--5", "DE92010265", Workshop on biophysical modelling of radiation effects,Padua (Italy),2-5 Sep 1991., and Holley, W.R.; Chatterjee, A.
- Funding Information:
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