Actions for SPECT assay of radiolabeled monoclonal antibodies [electronic resource].

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SPECT assay of radiolabeled monoclonal antibodies [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 1992.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
Pages: (66 pages) : digital, PDF file
Additional Creators
Duke University. Medical Center. Department of Radiology, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
The long-term goal of this research project is to develop methods to improve the utility of single photon emission computed tomography (SPECI) to quantify the biodistribution of monoclonal antibodies (MoAbs) labeled with clinically relevant radionuclides (¹²³I, ¹³¹I, and ¹¹¹In) and with another radionuclide,²¹¹At, recently used in therapy. We describe here our progress in developing quantitative SPECT methodology for ¹¹¹In and ¹²³I. We have focused our recent research thrusts on the following aspects of SPECT: (1) The development of improved SPECT hardware, such as improved acquisition geometries. (2) The development of better reconstruction methods that provide accurate compensation for the physical factors that affect SPECT quantification. (3) The application of carefully designed simulations and experiments to validate our hardware and software approaches.
Report Numbers
E 1.99:doe/er/60894-4
doe/er/60894-4
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
02/01/1992.
"doe/er/60894-4"
"DE92019915"
Jaszczak, R.J.
Funding Information
FG05-89ER60894
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