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Mutagenicity of photochemically-transformed polycyclic aromatic amines [electronic resource].

Published
Los Alamos, N.M. : Los Alamos National Laboratory, 1985.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
Pages: 22 : digital, PDF file
Additional Creators
Los Alamos National Laboratory and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Polycyclic aromatic amines (PAA) constitute a class of suspect genotoxic chemicals found in certain energy-related complex organic mixtures. A variety of studies are reported on the photochemical transformation (oxidation) of polycyclic aromatic amines and the increase in genotoxicity of the resulting complex mixtures of radiation-generated products. Biological endpoints of cytotoxicity and mutagenicity were measured in the Ames/Salmonella standard-plate assay. Chemical fractionation and identification of various photoproducts was accomplished with h.p.l.c., uv and ir spectroscopic and mass spectrometric techniques. The benchmark PAA in these studies was aminofluorene (2-AF). Photooxidation of 2-AF can occur at both the exocyclic nitrogen and certain ring positions resulting in the formation of direct-acting and potent bacterial mutagens, including 2-nitrosofluorene, 2-nitrofluorene, and 2-nitrofluoren-9-one. UVA-irradiated 2-AF solutions also contain promutagenic compounds, i.e., is 2-aminofluoren-9-one. These results support the hypothesis that the critical step in the activation of major, identified direct-acting mutagenic 2-AF photoproducts is their reduction by bacterial nitroreductase enzymes to reactive hydroxylamines. Photochemical oxidation is an alternative mechanism of transforming PAA into direct-acting genotoxins. 24 refs., 5 figs.
Report Numbers
E 1.99:la-ur-85-3594
E 1.99: conf-851027-3
conf-851027-3
la-ur-85-3594
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
01/01/1985.
"la-ur-85-3594"
" conf-851027-3"
"DE86002394"
Health and environmental research on complex organic mixtures, Richland, WA, USA, 21 Oct 1985.
Whaley, T.W.; Strniste, G.F.; Okinaka, R.T.; Nickols, J.W.
Funding Information
W-7405-ENG-36
View MARC record | catkey: 14397510