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Initial studies of the inhalation toxicity of beryllium sulfate and beryllium metal fume [electronic resource].

Published
Rochester, N.Y. : University of Rochester. Atomic Energy Project, 1947.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
pages 102-105 : digital, PDF file
Additional Creators
University of Rochester. Atomic Energy Project and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Data from 56 animals were collected to supply information relevant to the poisonous effects, including the organs injured and the route of the damage, caused by the inhalation of beryllium sulfate tetrahydrate dust at a concentration approximating 90 mg of the salt per cubic meter of air. Six criteria of toxicity were utilized in evaluating the information obtained from the animals which comprised 2 dogs, 3 rabbits, 10 rats, 14 guinea pigs, 20 mice and 7 hamsters. The animals were exposed 6 hours daily for a two-week period, a total of 66 hours, to a dust of this soluble beryllium salt in a small inhalation exposure chamber. Mortality for all species dying as a result of exposure was 43% of the 56 exposed animals or 20 of 20 mice, 2 of 10 rats, and 2 of 7 hamsters. The mice died from the 3rd to the 11th calendar day with an LD₅₀ being attained on the 7th day following the start of exposure. No deaths occurred among the dogs, rabbits, or guinea pigs. Weight response data showed that all species save the guinea pig were adversely affected. The rabbit lost 5% in weight, whereas the rat and hamster lost 11%. Clinical chemical values indicated renal impairment and some subsequent regeneration in the rabbits. Marked species variation, but unusually good conformity within each species, was thus observed in the response to the inhalation of beryllium sulfate. Rats were exposed by inhalation to beryllium metal fume at an approximate concentration of 800 mg/m³ of air under a variety of exposure schedules to determine the character of the toxic response. It was concluded that beryllium metal fume acts as a primary irritant which, when administered rapidly in high dosage, may be fatal but which is tolerated relatively well as long as no single dose exceeds 12,000 CT units. No cumulative poisonous effects were seen. 14 figs., 3 tabs.
Report Numbers
E 1.99:m--1997
m--1997
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
09/01/1947.
"m--1997"
"DE95013624"
Sprague, G.F.; LaBelle, W.; Pettengill, A.G.
View MARC record | catkey: 14404550