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Experimental evaluation of skin carcinogenicity associated with chronic exposure to synthetic petroleums [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 1980.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
Pages: 23 : digital, PDF file
Additional Creators
Oak Ridge National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Most fossil liquids, whether natural or synthetic, possess some degree of skin carcinogenic activity if applied at high enough concentration for sufficient time to genetically responsive experimental animals. Whether a synthetic petroleum shown to be capable of eliciting skin cancer in the mouse will have similar capability in exposed humans depends upon the potency of the material, the dosage and the person's individual susceptibility. This presentation describes the approach being taken to quantitiate skin carcinogenic potency. In addition to potency estimation, exposure conditions that could have an important bearing upon extrapolation of experimental animal data are investigated. These factors include the capacity of the material to induce skin irritation, and physical-chemical characteristics that influence skin localization and persistence of potentially carcinogenic components.
Report Numbers
E 1.99:conf-800758--1(draft)
conf-800758--1(draft)
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
01/01/1980.
"conf-800758--1(draft)"
Toxicology forum on safety assessment for specific compounds, Aspen, CO, USA, 27 Jul 1980.
Holland, J. M.
Funding Information
W-7405-ENG-26
View MARC record | catkey: 14673589