The coordination chemistry of technetium and rhenium and applications to nuclear medicines. [Annual] technical report, April 1, 1993--December 31, 1993 [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 1993.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- 9 pages : digital, PDF file
- Additional Creators:
- United States. Department of Energy
United States. Department of Energy. Office of Scientific and Technical Information
- The dramatic dependence of Re-binding to functionalized hydrazines on the nature of the coligands associated with the metal site has led to an examination of alkoxy and thiolato ligand types. The observation that multidentate thiolate ligands are highly effective in this latter role suggests the design and synthesis of new chelating polythiolate ligands with high binding affinities for radiometallic nuclides and of functionalized polythiolate ligands for the preparation of radionuclide-conjugated antibodies or peptides and the preparation and characterization of their complexes not only with the Group 7 metals Tc and Re but with the Group 13 metals Ga and In, which also possess radionuclides with useful properties. Since the rational design of these novel bifunctional conjugates requires a fundamental understanding of the coordination chemistry of relevant metals with polythiolate ligands whose syntheses and properties remain unexplored, effort has been directed toward the preparation of novel polythiolate ligands and the characterization of their complexes with Group 7 and Group 13 metals. This report describes studies on several complementary aspects of the coordination chemistry of the pyridinethiolate derived ligands 2-HSC₅NH₃-SiR₃, 2-HSC₅NH₃-6-SiR₃ and 2-HSC₅NH₂-3,6-SiR₃ and the potentially bifunctional polythiolate ligand HOOCCH₂Si(CH₂CH₂SH)₃ have been synthesized; of several aspects of rhenium-hydrazido and rhenium-thiolate chemistry have been developed; of Ga and In complexes of the 2-pyridinethiolate class of ligands have been synthesized and structurally characterized; and of the general coordination properties of the 2-pyrithinethiolate and related ligand types.
- Published through SciTech Connect.
Rhenium-Catecholato complexes and their reactivity with organohydrazines,Chicago, IL (United States),22-27 Aug 1993.
Syracuse Univ., NY (United States)
- Type of Report and Period Covered Note:
- Annual; 12/31/1993 - 12/31/1993
- Funding Information:
View MARC record | catkey: 14760274