Synthesis and in-vivo detection of boronated compounds for use in BNCT [electronic resource].

Published:: Washington, D.C : United States. Dept. of Energy. Office of Energy Research, 1991.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:: Pages: (10 pages) : digital, PDF file
Additional Creators:: University of Tennessee Medical Center at Knoxville, United States. Department of Energy. Office of Energy Research, and United States. Department of Energy. Office of Scientific and Technical Information

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Summary:

The primary objectives of the DOE Program at the University of Tennessee Biomedical Imaging Center are the development of new boron-neutron-capture agents as well as the technology to detect boron compounds in-vivo. The detection technology focuses on the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring BNCT agents in-vivo. A significant portion of the effort is directed toward the design of boron-containing neutron-capture-therapy agents. The UT -- DOE program is unique in that it has access to two state-of-the-art multinuclear magnetic resonance imaging units housed in the Biomedical Imaging Center at the University of Tennessee Medical Center at Knoxville. In addition the UT -- DOE researchers actively collaborate with colleagues at other DOE facilities (Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory and Oak Ridge Associated Universities). An important goal of the DOE program at UT is to provide training for students (predoctoral and postdoctoral). The University of Tennessee is one of the very few institutions in the world where students have hands-on'' access to both modern scientific equipment and medical imaging modalities such as the clinical MRI units. The academic nature of the program facilitates collaborative interactions with other DOE programs and helps to insure the continued availability of skilled scientists dedicated to the advancement of diagnostic medical procedures. 14 refs., 3 figs.

Report Numbers:

E 1.99:doe/er/60892-2
doe/er/60892-2

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Note:

Published through SciTech Connect.
02/01/1991.
"doe/er/60892-2"
"DE91007528"
Kabalka, G.W.

Funding Information:

FG05-89ER60892

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