High-level production of C-11-carboxyl-labeled amino acids. [For use in tumor and pancreatic imaging] [electronic resource].
- Washington, D.C : United States. Dept. of Energy. Assistant Secretary for Environment, Safety, and Health, 1979. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- Pages: 13 : digital, PDF file
- Additional Creators:
- Oak Ridge National Laboratory, United States. Department of Energy. Assistant Secretary for Environment, Safety, and Health, and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- Carbon-11-labeled amino acids have significant potential as agents for positron tomographic functional imaging. We have developed a rapid, high-temperature, high-pressure modification of the Buecherer--Strecker amino acid synthesis and found it to be quite general for the production of C-11-carboxyl-labeled neutral amino acids. Production of C-11-carboxyl-labeled DL-tryptophan requires certain modifications in the procedure. Twelve different amino acids have been produced to date by this technique. Synthesis and chromatographic purification require approximately 40 min, and C-11-carboxyl-labeled amino acids have been produced in yields of up to 425 mCi. Two C-11-carboxyl-labeled amino acids are being investigated clinically for tumor scanning and two others for pancreatic imaging. Over 120 batches of the various agents have been produced for clinical use over a three-year period.
- Published through SciTech Connect., 01/01/1979., "conf-790321--4", 2. international symposium on radiopharmaceuticals, Seattle, WA, USA, 18 Mar 1979., Hayes, R. L.; Sun, T. T.; Washburn, L. C.; Byrd, B. L.; Butler, T. A.; Callahan, A. P., and Oak Ridge Associated Universities, Inc., TN (USA). Medical and Health Science Div.
- Funding Information:
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