Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake [electronic resource].
- Washington, D.C : United States. Dept. of Energy. Assistant Secretary for Environment, Safety, and Health, 1979.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- Pages: 11 : digital, PDF file
- Additional Creators:
- Oak Ridge National Laboratory
United States. Department of Energy. Assistant Secretary for Environment, Safety, and Health
United States. Department of Energy. Office of Scientific and Technical Information
- These studies were directed at determining if the telluro fatty acids prepared by the isosteric replacement of the ..delta../sup 9/-double bonds of oleic and palmitoleic acids with /sup 123m/Te would show heart uptake in rats. The isostere of palmitoleic acid, 9-tellurapentadecanoic acid(II), was prepared by basic hydrolysis of the product formed by the coupling of /sup 123m/Te-sodium hexyl tellurol with methyl-8-bromooctadecanoate. Similarly, the isostere of oleic acid, 9-telluraheptadecanoic acid(IV), was prepared by the same route beginning with the reaction of /sup 123m/Te-sodium octyl tellurol with methyl-8-bromooctadecanoate. Both /sup 123m/Te-(II) and /sup 123m/Te-(IV) showed remarkably high heart uptake in rats (2 to 3% dose/gm) ten minutes after intravenous administration, and the heart/blood ratios were high (20-30/1). Finally, the hearts of rats injected with /sup 123m/Te-(IV) have been clearly imaged with a rectilinear scanner.
- Published through SciTech Connect.
2. international symposium on radiopharmaceuticals, Seattle, WA, USA, 18 Mar 1979.
Knapp, Jr., F. F.; Callahan, A. P.; Ambrose, K. R.; Grigsby, R. A.; Irgolic, K. J.
- Funding Information:
View MARC record | catkey: 14761439