A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT [electronic resource].

Published: Washington, D.C. : United States. Dept. of Energy, 1992.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description: Pages: (7 pages) : digital, PDF file
Additional Creators: Brookhaven National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information

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Summary

Treatment planning for clinical trials with boron neutron capture therapy (BNCT) is complicated substantially by the fact that the radiation field generated by the activating external neutron beam is composed of several different types of radiation, i.e., fast neutrons, recoil protons from elastic collisions with hydrogen, gamma rays from the reactor and from neutron capture by body hydrogen, protons from nitrogen capture, and the products of the NCT interaction. Furthermore, the relative contribution of each type of radiation varies with depth in tissue. Because each of these radiations has its own RBE, and the RBE of the fast neutron component will not be constant as the neutron spectrum changes with depth, the problem of predicting the severity of the biological effect, in depth, becomes complex indeed. In order to attack this problem, Monte Carlo calculations of dose, checked against benchmark measurements, are employed. Two approaches are then used to assess the severity of the effect. In the first, the effective dose (D[sub EF]) is determined by summing the products of (D[center dot]RBE) for each radiation. The other approach involves placing cells at the location for which the D[sub EF] was calculated. Using a dose-response curvefrom a low-LET radiation, e.g. [sup 137]Cs gamma rays (D[sub [gamma]Ca]), the photon equivalent dose (PED, or D[sub P]) can be determined. If the RBE values used are correct, the D[sub EF] and the D[sub P] should be essentially identical.

Report Numbers

E 1.99:bnl-48322
E 1.99: conf-9209280--8
conf-9209280--8
bnl-48322

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Note

Published through SciTech Connect.
01/01/1992.
"bnl-48322"
" conf-9209280--8"
"DE93006646"
Neutron capture therapy for cancer, Columbus, OH (United States), 13-17 Sep 1992.
Bond, V.P.; Liu, H.B.; Gordon, C.R.; Laster, B.H. University Hospital, Stony.

Funding Information

AC02-76CH00016

View MARC record | catkey: 14793187