Actions for DNA-nuclear matrix interactions and ionizing radiation sensitivity [electronic resource].

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DNA-nuclear matrix interactions and ionizing radiation sensitivity [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 1993.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
11 pages : digital, PDF file
Additional Creators
Argonne National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
The association between inherent ionizing radiation sensitivity and DNA supercoil unwinding in mammalian cells suggests that the DNA-nuclear matrix attachment region (MAR) plays an important role in radiation response. In radioresistant cells, the MAR structure may exist in a more stable, open configuration, limiting DNA unwinding following strand break induction and maintaining DNA ends in close proximity for more rapid and accurate rejoining. In addition, the open configuration at these matrix attachment sites may serve to facilitate rapid DNA processing of breaks by providing (1) sites for repair proteins to collect and (2) energy to drive enzymatic reactions.
Report Numbers
E 1.99:anl/bim/cp--78938
E 1.99: conf-930295--1
conf-930295--1
anl/bim/cp--78938
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
03/01/1993.
"anl/bim/cp--78938"
" conf-930295--1"
"DE93009209"
6. international environmental and molecular mutagenesis: the molecular basis of chromosomal aberrations,Castlemaine (Australia),17-20 Feb 1993.
Schwartz, J.L.; Vaughan, A.T.M.
Funding Information
W-31109-ENG-38
FG02-88ER60661
View MARC record | catkey: 14793493