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Control of mammalian cell mutagenesis and differentiation by chemicals which initiate or promote tumor formation [electronic resource].

Published
Oak Ridge, Tenn. : University of Tennessee, Knoxville, 1980.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
Pages: 22 : digital, PDF file
Additional Creators
University of Tennessee, Knoxville and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
A cell-mediated mutagenesis assay was developed to predict the potential carcinogenic hazard of some environmental chemicals. In this assay, Chinese hamster V79 cells, which are susceptible to mutagenesis, are co-cultivated with cells capable of metabolizing chemical carcinogens. Use of this assay made it possible to demonstrate a relationship between the degree of carcinogenicity and mutagenicity of a series of polycyclic hydrocarbons and nitrosamines and to study the organ specificity exhibited by some chemical carcinogens. However, most short-term in vitro assays are designed to detect mutagenic activity and therefore do not detect tumor promoting agents which are devoid of this activity. By analyzing various markers of terminal differentiation in cultured human melanoma and myeloid leukemia cells, we have established a relationship between the activity of a series of tumor promoting phorbol diesters in the mouse skin and their ability to induce terminal differentiation. We suggest that measuring alterations in the differentiation characteristics of some cultured cells may represent an approach by which environmental tumor promoting agents can be studied and detected.
Report Numbers
E 1.99:conf-8006117-1
conf-8006117-1
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Note
Published through SciTech Connect.
01/01/1980.
"conf-8006117-1"
Workshop on biological carcinogenesis, Detroit, MI, USA, 11 Jun 1980.
Huberman, E.; Jones, C. A.
Funding Information
W-7405-ENG-26
View MARC record | catkey: 14793787