Actions for Radiation-induced mutagenicity and lethality in Salmonella typhimurium [electronic resource].

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Radiation-induced mutagenicity and lethality in Salmonella typhimurium [electronic resource].

Published
Cleveland, Ohio : Case Western Reserve University, 1983.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
Pages: 3 : digital, PDF file
Additional Creators
Case Western Reserve University and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
The mutagenic and lethal effects of ionizing radiation on histidine-deficient auxotrophs of Salmonella typhimurium were studied to improve the understanding of radiation damage to DNA. The auxotrophs were divided into two groups - one which is sensitive to base-pair substitutions and another sensitive to frameshifts. These groups were composed of parent-daughter pairs in which the chemical mutagenicity enhancing plasmid, pKM101, is absent in the parent strain and present in the daughter. Co-60 ..gamma..-radiation and 250 kV x-rays were used to irradiate the bacteria. Irradiation of the frameshift - sensitive strains which carry the pKm101 plasmid doubled the absolute number of induced revertants whereas irradiation of the base-pair substitution sensitive strain which also carries the pKm101 plasmid produced nearly no change in the number of induced revertants. A nearly negligible effect on the mutation rate was observed for all parent strains. (ACR)
Report Numbers
E 1.99:conf-830710-3
conf-830710-3
Subject(s)
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Note
Published through SciTech Connect.
01/01/1983.
"conf-830710-3"
"DE83014653"
7. international conference of radiation research, Amsterdam, Netherlands, 3 Jul 1983.
Bakale, G.; Isildar, M.
Funding Information
AC02-78EV04746
View MARC record | catkey: 14793972