Quantitative mutagenesis and mutagen screening with Chinese hamster ovary cells [electronic resource].
- Oak Ridge, Tenn. : University of Tennessee, Knoxville, 1980.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- Pages: 23 : digital, PDF file
- Additional Creators:
- University of Tennessee, Knoxville and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- A summary is presented on the development of a specific gene mutation assay, the Chinese hamster ovary cells/hypoxanthine-guanine phosphoribosyl transferase (CHO/HGPRT) system, and the utilization of this system to study structure-activity relationship affecting cytotoxicity and gene mutation by various carcinogens. Then, preliminary development and validation of a Multiplex CHO System for the simultaneous determination of chromosome aberration, sister chromatid exchange in addition to cytotoxicity and gene mutation is presented. The potential use of a CHO/human cell hybrid system for measuring chromosomal deletion and loss is discussed.
- Report Numbers:
- E 1.99:conf-800485-1
- Published through SciTech Connect.
Workshop on the predictive value of in vitro short-term screening tests in carcinogenicity evaluation, Koevordon, Netherlands, 28 Apr 1980.
Hsie, A.W.; San Sebastian, J.R.; Tan, E.L.
- Funding Information:
View MARC record | catkey: 14794113