Osteosarcomas among beagles exposed to /sup 239/Plutonium. Technical report No. 34 [electronic resource].
- Published:
- Washington, D.C. : United States. Dept. of Energy, 1980.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy. - Physical Description:
- Pages: 30 : digital, PDF file
- Additional Creators:
- Stanford University. Department of Statistics, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
Access Online
- Restrictions on Access:
- Free-to-read Unrestricted online access
- Summary:
- A Weibull distribution was fit to the osteosarcoma death times of beagles given single intravenous injections of /sup 239/Pu. For injected doses in the range 0 to 1 ..mu..Ci/kg the osteosarcoma incidence rate h(t) at t days after injection can be fit by a quadratic function of the injected dose. The best fitting linear function was rejected by the data (p < 0.001). A different formula for h(t), derived from amultistage theory for osteosarcoma induction, was also fit to these data. For this purpose microdosimetry calculations were used to estimate the dose to the cells at risk in the endosteal layer (endosteal dose). According to the best fit, h(t) is a quadratic function of endosteal dose at low doses. A linear dose-response relationship was agan rejected. The absence of a linear component at low doses might be explained by the fact that 108 of the 185 animals injected at the lowest doses (< 0.02 ..mu..Ci/kg) were still alive at the time these data were collected.
- Report Numbers:
- E 1.99:doe/ev/02874-68
doe/ev/02874-68 - Subject(s):
- Other Subject(s):
- Bone Tissues
- Microdosimetry
- Carcinogenesis
- Dose-Response Relationships
- Osteosarcomas
- Radioinduction
- Plutonium 239
- Skeleton
- Biological Radiation Effects
- Beagles
- Experimental Data
- Graphs
- Intravenous Injection
- Mortality
- Single Intake
- Statistics
- Tables
- Actinide Isotopes
- Actinide Nuclei
- Alpha Decay Radioisotopes
- Animals
- Biological Effects
- Body
- Connective Tissue
- Data
- Data Forms
- Diseases
- Dogs
- Dosimetry
- Even-Odd Nuclei
- Heavy Nuclei
- Information
- Injection
- Intake
- Isotopes
- Mammals
- Mathematics
- Neoplasms
- Nuclei
- Numerical Data
- Organs
- Pathogenesis
- Plutonium Isotopes
- Radiation Effects
- Radioisotopes
- Sarcomas
- Skeletal Diseases
- Tissues
- Vertebrates
- Years Living Radioisotopes
- Note:
- Published through SciTech Connect.
03/01/1980.
"doe/ev/02874-68"
McMillan, A; Whittemore, A S. - Funding Information:
- AC02-EV02874
View MARC record | catkey: 14794443